Persistently sad, anxious, angry, irritable, or "empty" mood
Feelings of hopelessness, pessimism
Feelings of guilt, worthlessness, helplessness
Loss of interest or pleasure in hobbies and activities that were once enjoyed
Insomnia, early-morning awakening, or oversleeping
Decreased appetite and/or weight loss or overeating and/or weight gain
Fatigue, decreased energy, being "slowed down"
Crying spells
Thoughts of death or suicide, suicide attempts
Restlessness, irritability
Difficulty concentrating, remembering, making decisions
Persistent physical symptoms that do not respond to treatment, such as headaches, digestive disorders, and/or chronic pain
Poor school performance
Persistent boredom